Is zinc a key player in cartilage destruction in osteoarthritis?
April 30, 2014
Keeping you up-to-date with more developments in the research into osteoarthritis:
A recent study reveals that osteoarthritis-related tissue damage may be caused by abnormally high levels of a protein called ZIP8, which is embedded in the plasma membrane of cartilage cells and is involved in transporting zinc inside of these cells from the outside environment molecular pathway that is involved in regulating and responding to zinc levels in cartilage cells.
“Our findings suggest that local depletion of zinc or pharmacological inhibition of ZIP8 function or MTF1 activity in cartilage tissue would be effective therapeutic approaches for the treatment of osteoarthritis,” says Jang-Soo Chun of the Gwangju Institute of Science and Technology. “We are hopeful that this research will lead to the discovery and rapid development of novel drugs to suppress the progression of this debilitating disease.”